How it happens? Occurs in two parts:
- Initial insult
- Decreased myocardial contractility
- Decreased stroke volume
- Decreased left ventricular emptying
- Left ventricular dilation and backup of blood
- Increased preload
- Pulmonary congestion
- Initial insult
- Decreased myocardial contractility
- Decreased stroke volume
- Increased heart rate
- Decreased coronary artery perfusion and collateral blood flow
- Myocardial hypoxia
- Decreased cardiac output
- Compensation
- Decompensation and death.
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