How does this happen?
- Decreasing number of functioning nephrons
- Increased solute load from each nephrons à Alteration in GFR
- Reduced renal reserve: GFR of 35% to 50% of normal (No signs of impaired renal function)
- Renal insufficiency: GFR of 20% to 35% of normal (Possible hypertension, azotemia, and anemia)
- Renal failure: GFR of 20% to 25% of normal (Uremia, neurologic, cardiovascular, and GI symptoms)
- End-stage renal failure: GFR less than 20% of normal (Atrophy and fibrosis in renal tubules).