Thursday, April 28, 2011

Understanding Lupus

Systemic lupus erythematosus is a chronic inflammatory autoimmune disorder of the connective tissue affecting multiple organs. It is characterized by recurring remissions and exacerbations which predominantly affecting women.

How it happens?

  • Immune dysregulation in the form of autoimmunity 
  • B-cell hyperactivity 
  • Causing body to produce antibodies against its own cell components 
  • Activation of immune response by formed antigen-antibody complexes 
  • Production of antibodies against many different tissue components (RBCs, neutrophils, platelets, lymphocytes) or almost any organ or body tissue 
  • Widespread degeneration of connective tissue 
  • Possible cardiovascular, renal, and neurologic complication 
  • Severe bacterial infections

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