Rhabdomyolysis is characterized by the breakdown of muscle fibers. There is a good prognosis of rhabdomyolysis if the contributing causes are alleviated or the disease is treated before damage becomes irreversible. If this is unchecked, it can cause renal failure.
How does it happen?
- Direct injury to muscle fibers (sarcolemma)
- Increased intracellular sodium ion concentration
- Enhanced enzyme activity and interaction between actin and myosin
- Further muscle damage
- Leakage of myoglobin, potassium, and creatine kinase into the bloodstream
- Myoglobin trapped in renal capillaries or tubule
- Acute renal failure.
A leakage of myoglobin may alter kidney filtration.